Effects of cocaine and alcohol use in pregnancy on neonatal growth and neurobehavioral status. Coles CD. Platzman KA. Smith I. James ME. Falek A. Neurotoxicology & Teratology. 14(1):23-33, 1992 Jan-Feb.
Effects on fetal growth and neonatal behavior of cocaine
and alcohol use in pregnancy were investigated in infants born to women
in a low-income, predominantly black population. Despite the increased
use of cocaine by pregnant women and the accompanying public concern,
behavioral studies of exposed neonates are limited in number and scope.
In most studies, confounding factors (e.g., polydrug abuse, prematurity,
infant health status) have not been controlled so the actual effects
of cocaine and other drug exposure are not clear. Accordingly, this
study investigated effects of prenatal drug exposure although controlling
experimentally for other factors known to be associated with poor outcomes
in infants: prematurity, other illicit drug use, associated diseases
(e.g., sexually transmitted diseases [STDs]), and duration of drug use.
In addition, other factors statistically controlled were: experimenter
effects, timing of assessment, and effects of duration, amount, and
frequency of cocaine, alcohol, marijuana, and nicotine exposure. One
hundred and seven full-term infants were assessed at 2, 14, and 28 days
using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) by
testers blind to infant status. Growth factors (i.e., birthweight, length,
head circumference) were also assessed.
|All Rights Reserved 2004|