Magnetic Resonance Spectroscopy in Patients
Undergoing Treatment with Interferon-Alpha
and in Patients with Major Depression
The following research study is currently active:
Central effects of Interferon-Alpha Therapy
in Patients with Chronic Hepatitis An Imaging Study Using Functional Magnetic Resonance Spectoscopy
to Reveal Central Nervous System Mechanisms of Cytokine-Induced Behavioral Change
Cytokines released by an activated immune system have been associated with the development of depression in both medically ill and medically healthy individuals. The proposed research will explore the mechanism of these effects by using advanced neuroimaging strategies to measure brain metabolism before and after interferon-alpha administration for chronic hepatitis C and relate changes in brain metabolism to interferon-alpha-induced behavioral changes.