Relevant Publications

2009

Miller, A.H., Maletic, V., Raison, C.L. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry. In Press

Raison, C.L., Borisov, A.S., Woolwine, B.J., Massung, B., Vogt, G., Miller, A.H. Interferon-alpha effects on diurnal hypothalamic-pituitary-adrenal axis activity: relationship with proinflammatory cytokines and behavior. Molecular Psychiatry, In Press.

Raison, C.L., Borisov, A.S., Majer, M., Drake, D.F., Pagnoni, G., Woolwine, B.J., Vogt, G., Massung, B., Miller, A.H. Activation of CNS inflammatory pathways by interferon-alpha: relationship to monoamines and depression. Biological Psychiatry, In Press.

Miller, A.H. Mechanisms of cytokine-induced behavioral changes: psychoneuroimmunology at the translational interface. (Norman Cousins Award Lecture). Brain, Behavior and Immunity, In Press.

Pace, T.W., Negi, L.T., Adame, D.D., Cole, S.P., Sivilli, T.I., Brown, T.D., Issa, M.J., Raison, C.L. Effect of compassion meditation on neuroendocrine, innate immune and behavioral responses to psychosocial stress. Psychoneuroendocrinology, 34:87-98, 2009.

Su, S., Miller, A.H., Snieder, H., Bremner, J.D., Ritchie, J., Maisano, C., Jones, L., Murrah, N.V., Goldberg, J., Vaccarino, V. Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart Study. Psychosom Med., In Press.

Hu, F., Pace, T.W., Miller, A.H. Interferon-alpha inhibits glucocorticoid receptor-mediated gene transcription via STAT-5 activation in mouse HT22 cells. Brain, Behavior and Immunity, In Press.

Bull SJ, Huezo-Diaz P, Binder EB, Cubells JF, Ranjith G, Maddock C, Miyazaki C, Alexander N, Hotopf M, Cleare AJ, Norris S, Cassidy E, Aitchison KJ, Miller AH, Pariante CM. Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. Molecular Psychiatry, In Press.

2008

Miller, A.H., Ancoli-Israel, S., Bower, J.E., Capuron, L., Irwin, M.R. Neuroendocrine-immune mechanisms of behavioral co-morbidities in patients with cancer. Journal of Clinical Oncology, 26(6): 971-982, 2008.

Malemud, C.J., Miller, A.H. Pro-inflammatory cytokine-induced SAPK/MAPK and JAK/STAT in rheumatoid arthritis and the new anti-depression drugs. Expert Opinion on Therapeutic Targets, 12(2): 171-83, 2008.

Dai, J., Miller, A.H., Bremner, J.D., Goldberg, J., Jones, L., Shallenberger, L., Buckham, R., Murrah, N.V., Veledar, E., Wilson, P.W., Vaccarino, V. Adherence to the Mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study. Circulation, 117(2): 169-75, 2008.

Yu, W., Wang, E., Voll, R.J., Miller, A.H., Goodman, M.M. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem, 16(11): 6145-55, 2008.

Nater, U.M., Youngblood, L.S., Jones, J.F., Unger, E.R., Miller, A.H., Reeves, W.C., Heim, C. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome.  Psychosom Med, 70(3):298-305, 2008.

Majer, M., Welberg, L.A., Capuron, L., Pagnoni, G., Raison, C.L., Miller, A.H. IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C. Brain, Behavior, and Immunity, 22(6):870-80, 2008.

Capuron L, Su S, Miller AH, Bremner JD, Goldberg J, Vogt GJ, Maisano C, Jones L, Murrah NV, Vaccarino V. Depressive symptoms and metabolic syndrome: is inflammation the underlying link? Biol Psychiatry, 64(10):896-900, 2008.

Vaccarino V, Brennan ML, Miller AH, Bremner JD, Ritchie JC, Lindau F, Veledar E, Su S, Murrah NV, Jones L, Jawed F, Dai J, Goldberg J, Hazen SL. Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Biological Psychiatry, 64(6):476-83, 2008.

Yu W, Wang E, Voll RJ, Miller AH, Goodman MM. Synthesis, fluorine-18 radiolabeling, and in vitro characterization of 1-iodophenyl-N-methyl-N-fluoroalkyl-3-isoquinoline carboxamide derivatives as potential PET radioligands for imaging peripheral benzodiazepine receptor. Bioorg Med Chem, 16(11):6145-55, 2008.

Nater UM, Youngblood LS, Jones JF, Unger ER, Miller AH, Reeves WC, Heim C. Alterations in diurnal salivary cortisol rhythm in a population-based sample of cases with chronic fatigue syndrome. Psychosom Med, 70(3):298-305, 2008.

Su, S., Snieder, H., Miller, A.H., Ritchie, J., Bremner, J.D., Goldberg, J., Dai, J., Jones, L., Murrah, N.V., Zhao, J., Vaccarino, V. Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins. Atherosclerosis, 200(1):213-20, 2008.

Majer, M., Welberg, L.A., Capuron, L., Miller, A.H., Pagnoni, G., Reeves, W.C. Neuropsychological performance in persons with chronic fatigue syndrome: results from a population-based study. Psychosom Med. 70(7):829-36, 2008.

2007

Pace, T.W.W., Hu, F., Miller, A.H. Cytokine-effects on glucocorticoid receptor function: relevance to glucocorticoid resistance and the pathophysiology and treatment of major depression. Brain, Behavior and Immunity, 21(1):9-19, 2007.

Silverman, M.N., Macdougall, M.G., Raison, C.L., Miller, A.H. Endogenous glucocorticoids protect against TNF-alpha-induced increases in anxiety-like behavior in virally-infected mice. Molecular Psychiatry,) 12(4):408-417, 2007.

Raison, C.L., Woolwine, B.J., Demetrashvili, M.F., Borisov, A.F., Weinreib, R., Staab, J.P., Zajecka, J.M., Bruno, C.J., Henderson, M.A., Reinus, J.F., Evans, D.L., Asnis, G.M., Miller, A.H. Paroxetine for prevention of depressive symptoms induced by interferon-alpha plus ribavirin for hepatitis C. Alimentary Pharmacology and Therapeutics, 25(10):1163-1174, 2007.

Capuron, L., Pagnoni, G., Demetrashvili, M., Lawson, D.H., Fornwalt, F., Woolwine, B.J., Berns, G.S., Nemeroff, C.B., Miller, A.H.. Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology, 32(11): 2384-92, 2007.

Sanchez, M.M. Alagbe, O., Felger, J.C., Zhang, J., Graff, A.E., Grand, A.P., Maestripieri, D., Miller, A.H. Activated p38 MAPK is associated with decreased CSF 5-HIAA and increased maternal rejection during infancy in young adult rhesus monkeys, Molecular Psychiatry, 12(10): 895-897, 2007.

Felger, J.F., Alagbe, O., Hu, F., Mook, D., Freeman, A.A., Sanchez, M.M., Kalin, N.H., Ratti, E., Nemeroff, C.B., Miller, A.H. Effects of interferon-alpha on rhesus monkeys: a non-human primate model of cytokine-induced depression. Biological Psychiatry, 62(11): 1324-1333, 2007.

2006

Capuron, L., Welberg, L., Heim, C., Wagner, D., Solomon, L., Papanicolaou, D.A., Craddock, R.C., Miller, A.H., Reeves, W.C. Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome. Neuropsychopharmacology. 31(8):1777-1784, 2006

Pace, T.W.W., Mletzko, T.C., Alagbe, O., Musselman, D.L., Nemeroff, C.B. Miller, A.H., Heim, C.M. Increased stress-induced plasma IL-6 levels and mononuclear cell NF-kB activation in patients with major depression and increased early life stress. Am J Psychiatry, 163(9):1630-1633, 2006

Wang, X., Savage, R., Borisov, A., Rosenberg, R., Woolwine, B., Tucker, M., May, R., Feldman, J., Nemeroff, C.B., Miller, A.H. Efficacy of Risperidone versus Olanzapine in Patients with Schizophrenia Previously on Chronic Conventional Antipsychotic Therapy: A Switch Study. Journal of PsychiatricResearch, 40(7):669-76, 2006.

Raison, C.L., Capuron, C., Miller, A.H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology, 227:24-31, 2006.

2005

Miller, A.H., Capuron, L., Raison, C.L. Immunologic influences on emotion regulation.  Clin. Neurosci. Res, 4:325-333, 2005.

Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B.J., Nemeroff, C.B., Berns, G.S., Miller, A.H. Anterior cingulate activation and error processing during interferon-alpha treatment. Biological Psychiatry, 58:190-6, 2005.

Yoshida, K., Alagbe, O., Wang, X., Woolwine, B., Thornbury, M., Raison, C.L., Miller, A.H. Promoter polymorphisms of the interferon-alpha receptor gene and development of interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings. Neuropsychobiology, 52:55-61, 2005.

Raison CL. Demetrashvili M. Capuron L. Miller AH. Neuropsychiatric adverse effects of interferon-alpha: recognition and management. CNS Drugs. 19(2):105-23, 2005

Hu, F., Wang, X., Pace, T.W.W., Wu, H., Miller, A.H. Inhibition of COX-2 by celecoxib enhances glucocorticoid receptor function, Molecular Psychiatry, 10:426-428, 2005.

Wang, X., Wu, H., Lakdawala, V.S., Hu, F., Hanson, N.D. and Miller, A.H.  Inhibition of Jun N-terminal kinase (JNK) enhances glucocorticoid receptor-mediated function in mouse hippocampal HT22 cells.  Neuropsychopharmacology, 30:242-249, 2005.

Raison, C.L., Borisov, A.S., Broadwell, S.D., Capuron, L.C., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller, A.H. Depression during pegylated IFN-alpha plus ribavirin therapy: prevalence and prediction.  Journal of Clinical Psychiatry, 66(1):41-8, 2005.

Raison, C.L., Broadwell, S.D., Borisov, A.S., Manatunga, A.K., Capuron, L.C., Woolwine, B.J., Jacobson, I.M., Nemeroff, C.B., Miller,A.H. Depressive symptoms during IFN-alpha/ribavirin therapy are associated with reduced viral clearance in patients with hepatitis C. Brain Behavior and Immunity, 19(1):23-7, 2005.

2004

Newport, D.J., Heim, C., Bonsall, R., Miller, A.H., Nemeroff, C.B. Pituitary-adrenal responses to standard and low-dose dexamethasone suppression tests in adult survivors of child abuse. Biological Psychiatry, 55(1):10-20, 2004.

Asnis, G.M., De La Garza, R. 2nd., Miller, A.H., Raison, C.L. Ribavirin may be an important factor in IFN-induced neuropsychiatric effects. Journal of Clinical Psychiatry, 65(4):581, 2004.

Frick, B., Capuron, L., Schrocksnadel, K., Musselman, D.L., Lawson, D.H., Nemeroff, C.B. Miller, A.H., Fuchs, D. Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha. Journal of Interferon & Cytokine Research, 24(5):311-7, 2004.

Lee, B.N., Dantzer, R., Langley, K.E., Bennett, G.J., Dougherty, P.M., Dunn, A.J., Meyers, C.A., Miller, A.H., Payne, R., Reuben, J.M., Wang, X.S., Cleeland, C.S. A cytokine-based neuroimmunological mechanism of cancer-related symptoms. Neuroimmunomodulation, 11(5): 279-292, 2004.

Capuron, L., Miller, A.H. Cytokines and psychopathology: lessons from interferon alpha. Biological Psychiatry, 56(11):819-24, 2004.

Silverman, M.N., Miller, A.H., Biron, C.A., Pearce, B.D. Characterization of an IL-6 and ACTH dependent, immune to adrenal pathway during viral infection. Endocrinology, 145(8):3580-9, 2004.

Scheller-Gilkey, G., Moynes, K., Robinson, I., Kant, C., Miller, A.H.  Early life stress and PTSD symptoms in patients with comorbid schizophrenia and substance abuse. Schizophrenia Research, 69(2-3):167-74, 2004.

Capuron, L., Ravaud, A., Miller, A.H., Dantzer, R.  Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy. Brain Behavior and Immunity, 18:205-213, 2004.

Wang, X., Wu, H., Miller, A.H. Interleukin-1 alpha-induced activation of p38 mitogen-activated kinase inhibits glucocorticoid receptor function, Molecular Psychiatry, 9:65-75, 2004.

2003

Cleeland, C.S., Bennett, G.J., Dantzer, R., Dougherty, P.M., Dunn, A.J., Meyers, C.A., Miller, A.H., Payne, R., Reuben, J.M., Wang, X.S., Lee, B-N. Are the Symptoms of Cancer and Cancer Treatment due to a Shared Biologic Mechanism? A Cytokine-Immunologic Model of Cancer Symptoms. Cancer, 97:2919-25, 2003.

Scheller-Gilkey, G., Woolwine, B.J., Robinson, I.C., Gay, O., Moynes, K.A., Miller, A.H.  Relationship of clinical symptoms of substance use in schizophrenia patients on conventional versus atypical antipsychotics. American Journal of Drug and Alcohol Abuse, 29(3):553-66, 2003.

Raison, C.L., Miller, A.H. Cancer and depression: new developments regarding diagnosis and treatment, Biological Psychiatry, 54:283-294, 2003.

Capuron, L., Neurauter, G., Musselman, D.L., Lawson, D.H., Nemeroff, C.B., Fuchs, D., Miller, A.H. Interferon-Alpha-induced changes in tryptophan metabolism: relationship to depression and paroxetine treatment, Biological Psychiatry, 54:906-914, 2003.

Raison, C.L, Miller, A.H. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. American Journal of Psychiatry, 160:1554-1565, 2003.

Capuron, L.,  Raison, C.L., Lawson, D.H., Musselman, D.L., Su, Y., Nemeroff, C.B. Miller, A.H. An exaggerated HPA axis response to the initial injection of interferon-alpha is associated with depression during interferon alpha therapy, American Journal of Psychiatry.160(7):1342-1345, 2003.

Newport, D.J., Heim, C., Owens, M.J., Ritchie, J.C., Ramsey, C.H., Bonsall, R., Miller, A.H., Nemeroff, C.B. Cerebrospinal fluid CRF and vasopressin concentrations predict pituitary response in the CRF stimulation test: a multiple regression analysis. Neuropsychopharmacology. 28:569-576, 2003.