Division of Adult Outpatient Psychiatry
Behavioral Immunology Program
Dr. Andrew Miller is William P. Timmie Professor of Psychiatry and Behavioral Sciences and Director of Psychiatric Oncology at the Winship Cancer Institute at the Emory University School of Medicine in Atlanta, Georgia. He is an internationally recognized leader in the area of brain-immune interactions as they relate to stress and depression in both medically healthy and medically ill individuals including patients with cancer. His work focuses on the mechanisms by which cytokines cause depression in humans and non-human primates using chronic administration of the innate immune cytokine, interferon-alpha, as a model of chronic immune stimulation. Dr. Miller's work has shown that during chronic interferon-alpha treatment, cytokines access the brain and interact with the metabolism of relevant neurotransmitters including serotonin and dopamine. He has also shown that cytokines alter neurocircuits in the brain relevant to motivation and reward as well as anxiety and alarm. In addition, Dr. Miller has studied the impact of cytokines on neuroendocrine regulation as well as sleep including the study of specific signal transduction pathways that may be involved such as NF-kB and p38 mitogen activated protein kinase. Finally, Dr. Miller and his group are currently conducting clinical trials examining the efficacy of anti-inflammatory agents such as cytokine antagonists in patients with treatment resistant depression and patients with cancer. Dr. Miller has produced over 200 scholarly publications and edited a book entitled Depressive Disorders and Immunity. Dr. Miller’s research awards include the Curt Richter Award from the International Society of Psychoneuroendocrinology and the Norman Cousins Award from the Psychoneuroimmunology Research Society. Aside from his research endeavors, Dr. Miller is a Board Certified Psychiatrist and past examiner for the American Board of Psychiatry and Neurology.