Psychiatry and Behavioral Sciences
Human Psychophysiology of Emotion Laboratory
Trauma Recovery Program, Atlanta VA Medical Center
Phone: 404-321-6111, ext 4722
Seth Davin Norrholm, Ph.D. is a translational neuroscientist who studies the acquisition and extinction of learned fear in traumatized combat and civilian populations. The primary objective of his work is to develop “bench-to-bedside” clinical research methods to inform therapeutic interventions for posttraumatic stress disorder (PTSD). The most effective treatments for PTSD involve exposure therapy, a clinical analog to laboratory fear extinction, and as such there is a compelling need to further study these processes. Dr. Norrholm has developed a conditioned fear extinction paradigm using fear-potentiated startle; a methodology that has the potential to be an effective outcome measure for PTSD treatment as well as an index of fear recovery. His work has been supported by funding from the Brain and Behavior Foundation (formerly NARSAD), the Congressionally Directed Medical Research Program through the Department of Defense (CDMRP/DoD), and the Emory University Research Committee.
Dr. Norrholm collaborates with several researchers at Emory including Tanja Jovanovic, Kerry Ressler, Bekh Bradley, Kelly Skelton, Barbara Rothbaum, Helen Mayberg, and Erica Duncan. These collaborations are focused on the interaction between genetic and environmental risk factors that mediate vulnerability to developing PTSD, PTSD symptom severity, and treatment outcome, with a focus on the identification of intermediate phenotypes.
Dr. Norrholm and his collaborators have recently established a Human Psychophysiology of Emotion Laboratory that will bring together cutting edge psychophysiological techniques to study the neurobiology of fear, anxiety, and depression.