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Depression Biometrics Lab

Research Focus

My research examines neural systems mediating mood and emotions in health and disease with a primary emphasis on major depression and its recovery.  Functional neuroimaging (PET, fMRI, DTI) serve as the core methodologies, although all projects are multi-disciplinary (clinical trials, neurophysiology, personality structure, genetics, cognitive neuroscience, functional neurosurgery). Defining brain mechanisms underlying major depression and mediating its treatment are the primary goals, with an emphasis on development of algorithms that will discriminate patient subgroups, optimize treatment selection, and provide markers of disease and relapse vulnerability.  These studies further provide foundation for refinement and continued testing of Deep Brain Stimulation (DBS) for treatment resistant depression.